Research

Peer reviewed publications

  1. Lum PY, Singh G, Lehman A, Ishkanov T, Vejdemo-Johansson M, Alagappan M, Carlsson J, Carlsson G.Extracting insights from the shape of complex data using topology. Sci Rep. 2013; 3:1236. PMID: 23393618.
  2. Pollom EL, Alagappan M, von Eyben R, Kunz PL, Fisher GA, Ford JA, Poultsides GA, Visser BC, Norton JA, Kamaya A, Cox VL, Columbo LA, Koong AC, Chang DT. Single- versus multifraction stereotactic body radiation therapy for pancreatic adenocarcinoma: outcomes and toxicity. Int J Radiat Oncol Biol Phys. 2014 Nov 15; 90(4):918-25. PMID: 25585785.
  3. Alagappan M, Pollom EL, von Eyben R, Kozak MM, Aggarwal S, Poultsides GA, Koong AC, Chang DT. Albumin and Neutrophil-Lymphocyte Ratio (NLR) Predict Survival in Patients With Pancreatic Adenocarcinoma Treated With SBRT. Am J Clin Oncol. 2016 Jan 11. PMID: 26757436.
  4. Cui Y, Song J, Pollom E, Alagappan M, Shirato H, Chang DT, Koong AC, Li R. Quantitative Analysis of (18)F- Fluorodeoxyglucose Positron Emission Tomography Identifies Novel Prognostic Imaging Biomarkers in Locally Advanced Pancreatic Cancer Patients Treated With Stereotactic Body Radiation Therapy. Int J Radiat Oncol Biol Phys. 2016 Sep 1; 96(1):102-9. PMID: 27511850.
  5. Jiang D, Tam AB, Alagappan M, Hay MP, Gupta A, Kozak MM, Solow-Cordero DE, Lum PY, Denko NC, Giaccia AJ, Le QT, Niwa M, Koong AC. Acridine Derivatives as Inhibitors of the IRE1a-XBP1 Pathway Are Cytotoxic to Human Multiple Myeloma. Mol Cancer Ther. 2016 Sep; 15(9):2055-65. PMID: 27307600.
  6. Jiang D, Lynch C, Medeiros BC, Liedtke M, Bam R, Tam AB, Yang Z, Alagappan M, Abidi P, Le QT, Giaccia AJ, Denko NC, Niwa M, Koong AC. Identification of Doxorubicin as an Inhibitor of the IRE1a-XBP1 Axis of the Unfolded Protein Response. Sci Rep. 2016 Sep 16; 6:33353. PMID: 27634301.
  7. Alagappan M, Jiang D, Denko N, Koong AC. A Multimodal Data Analysis Approach for Targeted Drug Discovery Involving Topological Data Analysis (TDA). Adv Exp Med Biol. 2016; 899:253-68. PMID: 27325272.
  8. Pollom EL, Alagappan M, Park LS, Whittemore AS, Koong AC, Chang DT. Does radiotherapy still have a role in unresected biliary tract cancer? Cancer Med. 2017 Jan; 6(1):129-141. PMID: 27891822.
  9. Chen JH, Alagappan M, Goldstein MK, Asch SM, Altman RB. Decaying relevance of clinical data towards future decisions in data-driven inpatient clinical order sets. Int J Med Inform. 2017;102:71-79. PMID: 28495350
  10. Alagappan M, Richardson M, Schoen M, Muffly L, Tierney K, Jenkins P, Neri E, Kraemer H, Periyakoil VS. A Three-Step Letter Advance Directive Procedure to Facilitate Patient-Proxy Alignment in Advance Care Planning. Journal of Palliative Medicine. 2018 Sep. PMID: 30247088
  11. Alagappan M, Glissen Brown JR, Mori Y, Berzin TM. Artificial intelligence in gastrointestinal endoscopy: The future is almost here. World Journal of Gastrointestinal Endoscopy. 2018 Oct. PMID: 30364792
  12. Alagappan M, Darras N, Yang L, Vanderlaan P, Mizrahi M, Sawhney M, Pleskow D, Berzin TM. Yield of biliary stent cytology – Is it time to think lean? Endoscopy International Open. 2019 April. PMID:

Abstracts

  1. Jiang D, Zhang J, Alagappan M, Le QT, Koong A. Targeting the IRE1-XBP1 axis in unfolded protein response for cancer therapy. Abstract. Tumor Microenvironment Workshop, Miami, FL. 2013.
  2. Jiang D, Alagappan M, Yang Z, Johannet P, Lynch C, Le QT, Giaccia A, Denko N, Hay M, Niwa M, Koong A. Targeting the IRE1-XBP1 Pathway for Cancer Therapy. Abstract. 3rd International Conference on Tumor Microenvironment and Cellular Stress: Signaling, Metabolism, Imaging and Therapeutic Targets. Mykonos, Greece. 2014
  3. Pollom EL, Alagappan M, Chan C, Shultz D, Kunz PL, Koong A, Chang DT. Outcomes and toxicity of SBRT for patients with unresectable pancreatic adenocarcinoma. Abstract. ASCO GI Symposium, San Francisco, CA. 2014.
  4. Alagappan M, Pollom EL, von Eyben R, Kunz PL, Fisher GA, Poultsides GA, Visser B, Norton J, Columbo L, Koong AK, Chang DT. Albumin and neutrophil-lymphocyte ratio predict overall survival in patients with unresectable pancreatic adenocarcinoma treated with SBRT. Abstract. ASCO GI Symposium, San Francisco, CA. 2015.
  5. Alagappan M, Goldstein MK, Asch SM, Altman RB, Chen JH. Decaying relevance of clinical data when predicting future decisions. Abstract. AMIA Joint Summits on Translational Science, San Francisco, CA, 2017.

Presentations

  • “Decaying Relevance of Clinical Data When Predicting Future Decisions” – AMIA Joint Summits on Translational Science (March 2017, San Francisco, CA)